Perth County OPP closed Perth Road 86 between Listowel and Molesworth, Ont. on Tuesday after a transport truck rolled into the ditch.
The collision happened around 8:20 a.m., when police say a westbound transport had to take evasive action to avoid a head-on collision with an eastbound car and ended up in the north ditch.
The driver of the car was treated in hospital and released, while the driver of the transport truck was not injured.
The car's driver has been charged with careless driving.
The road was expected to remain closed from Road 169 to Road 172 until 3 p.m. to allow for clean-up of the scene.
OPP are asking drivers to avoid the area, and say they have already had to deal with five separate incidents of people driving through the road closure barrier.
They were each charged with driving on a closed roadway under the Highway Traffic Act, which includes a fine of $110 and three demerit points upon conviction.