While snow squall warnings have ended for areas north of London, Environment Canada has issued a special weather statement for much of the region.
Areas including Huron-Perth and Grey-Bruce already took a hit Monday, but areas to the southeast are expected to be hit with more snow Tuesday.
Environment Canada says nowfall amounts of five to 10 cm are likely as a low pressure system tracks across Lake Huron Tuesday morning.
London-Middlesex and Elgin County east through Oxford, Norfolk, Wellington and areas further east are all expected to see snow.
Along the eastern edge Lake Ontario, 10 to 15 cm of snow are possible are possible.
In addition, strong winds up to 70 km/h could cause local blowing snow and reduced visibility.
Drivers are asked to use caution as visibility may be suddenly reduced.
Updated watches and warnings for the region can be found on the Environment Canada website.