Grey Road 10 between Elmwood and Hanover was closed for most of the day following a fatal collision on Wednesday morning.
The two-vehicle crash involved a pickup and a transport truck. The driver of the pickup was killed.
OPP Sgt. Dave Rektor said in a Tweet that the road closure was between Concession Road 4 and Concession Road 8.
Grey County is reporting that road conditions in the area were generally bare and wet at the time.
No names have yet been released.
The road reopened around 5:30 p.m.