Sears Canada announced it is closing 59 stores, including the Sears Home location on Wharncliffe Road in London.
Sears Canada says it is seeking court protection from its creditors in order to restructure its business.
The struggling retailer has piled up losses and seen its stock nosedive, losing more than 80 per cent of its value in the last year.
All other local Sears Canada stores are expected to remain open. Other communities expected to lose stores include Sears Home in Windsor and the Sears outlets in Cambridge and Chatham-Kent.
In total, approximately 2,900 job losses are expected.
Just last week, the company warned there was "significant doubt" about its future and that it could be sold or restructured.
It has also gone through several leadership changes in recent years.
Here's a full list of the closures.
With files from The Canadian Press.