Ontario researchers say they've found what causes long-COVID symptoms
Researchers at Western University in London, Ont., say they have identified for the first time the cause of long COVID symptoms.
According to a press release issued Tuesday by Western, the LIVECOVIDFREE study, which is based at five centres throughout Ontario and spearheaded by Western professor Grace Parraga, is the largest MRI study of patients afflicted with long COVID.
The use of MRI technology — combined with inhaled xenon gas — allowed researchers to see that long-COVID symptoms are related to the microscopic abnormalities that affect how oxygen is exchanged from the lungs to the red blood cells.
The results of the study were published in the journal Radiology and reveal a potential cause for long-COVID symptoms.
“By understanding the cause, team members responsible for patient care have been able to target treatment for these patients,” the press release reads.
Long COVID is characterized by the feeling of brain fog, breathlessness, fatigue and limited capacity to do normal day-to-day things. The symptoms can last weeks or months following initial infection.
“I think it is always a conundrum when someone has symptoms, but you can't identify the problem. Because if you can't identify the problem, you can't identify solutions,” said Parraga, Tier 1 Canada research chair in lung imaging to transform outcomes at Western’s Schulich School of Medicine & Dentistry.
By having study participants inhale polarized xenon gas while inside an MRI, researchers could see in real time the function of the 300-500 million tiny alveolar sacs, which are about 1/5 of a mm in diameter and are responsible for delivering oxygen to the blood.
“With our MRI technique, we can watch in real-time the air moving through the alveolar membrane and through to the blood cells; and we can actually see the function of the tiny alveolar sacs in the lungs,” said Parraga. “What we saw on the MRI was that the transition of the oxygen into the red blood cells was depressed in these symptomatic patients who had had COVID-19, compared to healthy volunteers.”
Study participants with suspected long COVID were recruited from two London, Ont., hospitals -- London Health Sciences Centre's (LHSC) urgent COVID-19 care clinic and St. Joseph’s Health Care's post-acute COVID-19 program.
According to the release, some study participants were still symptomatic after 35 weeks. A one-year follow-up is now underway to better understand the results.
The study was done in collaboration with LHSC, St. Joseph’s, Lakehead University, McMaster University, Toronto Metropolitan University and Sick Kids Hospital in Toronto.
CTVNews.ca Top Stories
'A step forward': New screening criteria for sperm donors takes effect
Canadians looking to grow their families with the assistance of sperm or egg donations should soon have more options for donors as the federal health agency does away with longstanding restrictions criticized as discriminatory.
Ontario Provincial Police arrest 64 suspects in child sexual exploitation investigation
Ontario Provincial Police say 64 suspects are facing a combined 348 charges in connection with a series of child sexual exploitation investigations that spanned the province.
U.S. presidential candidate RFK Jr. had a brain worm, has recovered, campaign says
Independent U.S. presidential candidate Robert F. Kennedy Jr. had a parasite in his head more than a decade ago, but has fully recovered, his campaign said, after the New York Times reported about the ailment.
Police handcuff man trying to enter Drake's Toronto mansion
Toronto police say a man was taken into custody outside Drake's Bridle Path mansion Wednesday afternoon after he tried to gain access to the residence.
What is whooping cough and should Canadians be concerned as Europe declares outbreak?
There is currently a whooping cough epidemic in Europe, with 10 times as many cases compared to the previous two years. While an outbreak has not been declared nationwide in Canada, whooping cough is regularly detected in the country.
Pfizer agrees to settle more than 10K lawsuits over Zantac cancer risk: Bloomberg News
Pfizer has agreed to settle more than 10,000 lawsuits about cancer risks related to the now discontinued heartburn drug Zantac, Bloomberg News reported on Wednesday, citing people familiar with the deal.
Steve Albini, legendary producer for Nirvana, the Pixies and an alternative rock pioneer, dies at 61
Steve Albini, an alternative rock pioneer and legendary producer who shaped the musical landscape through his work with Nirvana, the Pixies, PJ Harvey and more, has died. He was 61.
Case against ex-Mountie charged with helping China can go ahead in Quebec, judge says
A Quebec court judge has ruled that the case against a former RCMP officer charged with helping China conduct foreign interference can go ahead in the province.
Ippei Mizuhara, ex-interpreter for baseball star Shohei Ohtani, will plead guilty in betting case
The former interpreter for Los Angeles Dodgers star Shohei Ohtani has agreed to plead guilty to bank and tax fraud in a sports betting case in which prosecutors allege he stole nearly US$17 million from the Japanese baseball player to pay off debts, federal prosecutors said Wednesday.