Oxford County OPP are investigating the report of a missing woman from Norwich Township and are asking for public help.
Karen Elsbrie, 55, last had contact with her family on Wednesday around 5 a.m.
Police are concerned about her welfare.
Her vehicle was found at the Highway 401 and Highway 19 car park and OPP are searching in the Ingersoll area.
Elsbrie is described as having a medium build, weighing around 140 pounds with dark shoulder-length straight brown hair and hazel eyes.
She is believed to be wearing black yoga-style pants, a light blue t-shirt and blue running shoes.
Anyone with information is asked to contact police at 1-888-310-1122 or Crimestoppers at 1-800-222-TIPS (8477).