Perth OPP have closed Line 86 between Perth Road 147 and Perth Road 140 near Listowel Friday after a crash that left a driver in serious condition and injured two children.

Police remain on scene of the two-car collision and say the road won't be open until 6 p.m.

A 39-year-old driver of a minivan from the Waterloo area had to be extricated from the vehicle after it collided with an  SUV around 1 p.m. The driver was taken by air ambulance to London.

Two children in the minivan, ages 10 and 8 had non-life threatening injuries.

The driver of the SUV, a 26 year-old from Tiny Township, was transported to an area hospital with minor injuries. This driver was treated and released.