Oxford County OPP closed Highway 401 eastbound early Wednesday morning at Drumbo Road following a fatal collision.
According to police, the collision involved two tractor trailers travelling eastbound at approximately 12:30 a.m.
Officers say one driver has died. He has been identified as 51-year-old Dale Boeru of Kitchener.
The other driver has been transported to hospital with non-life threatening injuries.
The collision is under investigation.