Middlesex OPP are investigating a collision involving a motorcycle on Townsend Line at Sexton Drive in Adelaide-Metcalfe Township.
The crash happened just before 1 p.m. Sunday afternoon, west of Strathroy.
Police say the motorcycle struck a canoe that had fallen off of a truck, causing the bike to lose control.
The male driver of the motorcycle was airlifted to LHSC with critical injuires.
His female passenger was taken to hospital with serious, but non life-threatening injuries.
Townsend Line between Sexton Drive and Wilson Line is expected to be closed to traffic for several hours as the investigation continues.
Police are asking the public to drive slowly in the area to ensure the safety of all involved.