Middlesex County OPP have closed Longwoods Road near Bothwell after a serious two-vehicle crash on Wednesday afternoon.

Emergency crews were called to the scene on Longwoods Road at Cashmere Road around 2:30 p.m. for a head-on collision involving a car and a pickup truck.

A female driver was transported to hospital but has since died as a result of her injuries. A male driver was also transported to hospital with non-life-threatening injuries.

No names have yet been released.

Members of the OPP Technical Traffic Collision Investigation team have been called in to assist in the investigation, and anyone who witnessed the crash is asked to contact police.

Longwoods Road has been closed between Sassafras Road and Clachan Road. It is expected to remain closed until late Wednesday evening.

Police are asking motorists to avoid the area.